Active substances synthesis

DMSO is widely used as a reaction solvent for active substances synthesis and has shown advantages in numerous reactions including:

addition	esterification
alkylation	elimination
cyclisation	substitution
etherification

DMSO is rated by EMEA as a ICH class 3 solvent: "Solvents with low toxic potential" while NMP, DMF and DMAC are rated class 2: "Solvents to be limited".

Click here to view the official EMEA report.

Moreover, compared to other polar aprotic solvent, DMSO improves yielding, selectivity and kinetic.

DMSO has all the qualities required for a reaction solvent:

1	High flash point	2	High solubility of organic compounds and salts
3	Stable in temperature under basic and neutral conditions	4	Reactions are faster than with other polar aprotic solvents
5	Easily recyclable	6	Not labeled